Introduction:
The TRIMDON product line is a trusted range of metabolic anti-ischemic agents containing Trimetazidine Hydrochloride in a sustained-release (SR) formulation. Unlike conventional antianginal drugs that affect hemodynamics (heart rate, blood pressure), TRIMDON-35 MR works by optimizing cellular energy metabolism, protecting cardiomyocytes from ischemia-induced damage without altering cardiac workload. Available in premium ALUMINIUM FOIL packaging (10 x 10 tablets), TRIMDON-35 MR ensures excellent product stability, moisture protection, and consistent therapeutic release for twice-daily dosing convenience.
Product Range & Benefits
TRIMDON-35 MR
-
Composition: Trimetazidine Hydrochloride 35 mg (Sustained Release)
-
Packaging: ALUMINIUM FOIL, 10 x 10 Tablets
-
Use: Indicated for the long-term management of angina pectoris, as an add-on therapy to first-line antianginal agents (beta-blockers, calcium channel blockers, nitrates), or in patients who are inadequately controlled by or intolerant to conventional therapies.
Indications:
-
Chronic stable angina pectoris (prophylactic treatment)
-
Adjunct therapy for angina not controlled by first-line treatments
-
Ischemic heart disease
-
Post-myocardial infarction recovery (symptomatic management)
-
Tinnitus and vertigo of vascular origin (off-label / as directed)
-
Retinal vascular disorders (off-label / as directed)
Dosage and Administration:
-
One tablet (35 mg) twice daily (morning and evening), with meals.
-
Swallow whole; do not crush, break, or chew the sustained-release tablet.
-
Regular monitoring of clinical response and tolerability is recommended.
-
Treatment is typically long-term; do not stop abruptly without physician advice.
Precautions & Warnings:
-
Contraindicated in Parkinson’s disease, parkinsonian symptoms, tremors, restless legs syndrome, and other movement disorders.
-
Contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73m²).
-
Not indicated for the treatment of acute angina attacks (use short-acting nitrates like sublingual nitroglycerin for acute episodes).
-
Use cautiously in patients with moderate renal impairment (eGFR 30-60 mL/min/1.73m²) – dose adjustment may be required.
-
May cause or worsen movement disorders (tremors, rigidity, gait instability); discontinue immediately if such symptoms develop.
-
Use during pregnancy and lactation only if clearly necessary and under medical supervision.
Drug Interactions:
-
No significant drug-drug interactions reported with commonly used cardiovascular medications (beta-blockers, calcium channel blockers, ACE inhibitors, statins, anticoagulants).
-
Can be safely co-administered with other antianginal agents.
Possible Side Effects:
-
Common: Dizziness, headache, abdominal pain, diarrhea, dyspepsia, nausea, vomiting, asthenia (weakness), fatigue
-
Uncommon: Palpitations, tachycardia, hypotension, vertigo, constipation, skin rash, pruritus, urticaria
-
Rare: Parkinsonian symptoms (tremors, rigidity, bradykinesia, gait instability), restless legs syndrome, sleep disturbances, nightmares
-
Very rare: Hepatitis, agranulocytosis, thrombocytopenia (discontinue if signs appear)
Special Warnings:
-
Trimetazidine is known to cause drug-induced parkinsonism, especially in elderly patients and those with renal impairment. Symptoms are usually reversible upon discontinuation within 4 months.
-
Evaluate patients regularly (every 3-6 months) for new onset or worsening of movement disorders.
-
Discontinue immediately if extrapyramidal symptoms appear.
Conclusion:
TRIMDON-35 MR (Trimetazidine Hydrochloride 35 mg SR) offers a unique metabolic approach to managing chronic stable angina pectoris. By optimizing myocardial energy metabolism without hemodynamic effects, it provides effective symptom control as an add-on therapy. With its convenient twice-daily sustained-release formulation and premium ALUMINIUM FOIL packaging, TRIMDON-35 MR ensures consistent anti-ischemic protection and patient compliance.
If you’re looking to buy Trimetazidine SR tablets online or for clinical use, trust TRIMDON-35 MR for proven antianginal efficacy, metabolic cardioprotection, and quality packaging.
Note : Always Consult a physician before taking any medication, and do not rely solely on this information for medical advice.
For more such product information and similar product category Cardiac
You can also contact us https://diabetes-cardiac.com/contact-us/
